Author

A. Strangio

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Review Open access Oct 2026

Inherited platelet function disorders: a comprehensive narrative review focusing on diagnostic and management aspects

Qualitative and quantitative inherited platelet disorders (IPDs) are a heterogeneous group of rare bleeding conditions caused by inherited variants in genes that affect platelet production and function. Clinically, IPDs are characterized by significant phenotypic heterogeneity, ranging from mild mucocutaneous bleeding...

Antonietta Ferretti, Nicola Portesi, Chiara Gorio et al. · Bleeding Thrombosis and Vasc... · 0 citations

Open access Oct 2026

PO060 | DISCREPANCY IN FACTOR VIII LEVELS AMONG HEMOPHILIA A CARRIERS: ONE-STAGE VS. CHROMOGENIC ASSAY

Background. Hemophilia A (HA) is an X-linked bleeding disorder caused by mutations in the F8 gene. While clinical focus is often on affected males, obligate and symptomatic carriers frequently exhibit reduced Factor VIII (FVIII) activity due to lyonization (X-chromosome inactivation). A significant diagnostic challenge...

A. Strangio · Bleeding Thrombosis and Vasc... · 0 citations

Open access Oct 2026

BEST-06 | OPTIMIZING LABORATORY MONITORING OF EFANESOCTOCOG ALFA: IMPACT OF APTT REAGENTS AND CHROMOGENIC ASSAYS ON DIAGNOSTIC ACCURACY

Background. Efanesoctocog alfa (FVIII-ULTRA) represents a paradigm shift in hemophilia. A treatment as a first-in-class recombinant factor VIII engineered for high, sustained activity. Due to its unique structural modifications—including the fusion of the D’D3 domain of von Willebrand factor and XTEN polypeptides—the m...

A. Strangio · Bleeding Thrombosis and Vasc... · 0 citations