A. Sorathia

The early-onset paradox: Advanced-stage colon cancer at presentation across socioeconomic and health system factors.

136 Background: Early-onset colon cancer (EOCC) incidence is rising sharply, yet younger patients consistently present with more advanced disease than older adults. This study investigates whether this stage discrepancy persists after adjusting for socioeconomic status (SES) and healthcare system factors, and e...

Journal of Community Hospital Internal Medicine Perspectives Journal of Community Hospital Internal Medicine Perspectives

Efficacy and safety of orforglipron 12 mg versus orforglipron 36 mg maintenance dose among patients with obesity with or without diabetes: a systematic review and comprehensive meta-analysis

Obesity is projected to affect about one billion adults by 2030 and is associated with cardiometabolic morbidity. Orforglipron is an oral, non-peptide glucagon-like peptide-1 receptor agonist developed to provide weight and metabolic benefits. Prior meta-analyses have supported its efficacy and safety but were limited...