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Open access Sep 2026

Multi-target blood test for hepatocellular carcinoma early detection: a cross-sectional analysis of the prospective ALTUS study.

BACKGROUND & AIMS Globally, 350 million people are at risk for HCC. Ultrasound screening is recommended but is limited by poor early-stage sensitivity and low adherence. This study evaluated whether the multi-target HCC blood test (mt-HBT) demonstrates non-inferior sensitivity for early-stage HCC compared with ultrasou...

Binu V. John, M. Camardo, A. Singal et al. · 0 citations
Open access Oct 2026

Evaluating a Polygenic Risk Score for Hepatocellular Carcinoma in Multiethnic Cirrhosis Patients in Texas

ABSTRACT Background and Aims Genome‐wide association studies (GWAS) that were previously conducted in European and Asian cohorts have identified numerous genetic risk factors for hepatocellular carcinoma (HCC) and its precursors and risk factors. A polygenic risk score (PRS) composed of these key SNPs for HCC may be us...

Priya B. Shetty, N. Choi, Hao T. Duong et al. · 0 citations
Review Oct 2026

Surveillance for Hepatocellular Carcinoma in Patients at High Risk.

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide and most often arises in patients with chronic liver disease and cirrhosis. Since curative treatment options are largely limited to early-stage disease, effective surveillance strategies are essential to improve outcomes. Cu...

Kathryn J. Fowler, A. Kamaya, S. Rodgers et al. · 0 citations

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