Peptide signaling in the paraventricular thalamus is essential for disrupted adult reward behaviors consequent to early-life adversity.
Early-life adversity (ELA) is strongly linked to emotional disorders characterized by dysregulated reward behaviors. However, the mechanisms by which transient neonatal experiences generate enduring, sex-specific alterations in brain function remain unresolved. Paraventricular thalamus (PVT) neurons are selectively act...