Doxorubicin Encapsulation in D-α-Tocopherol Succinate-Functionalized β-Cyclodextrin Enhances Intracellular Retention and Cytotoxicity in a Chemoresistant T-ALL Model
Therapeutic resistance remains a major limitation in T-cell acute lymphoblastic leukemia (T-ALL) and can reduce the efficacy of chemotherapeutic agents, including doxorubicin (DOXO). Since intracellular drug accumulation and retention are important determinants of DOXO activity, we evaluated whether its encapsulation i...