Open access
Aug 2026
Biased stochastic motor dynamics drive bidirectional, processive translocation by the AAA+ disaggregase Hsp104
Protein aggregation disrupts proteostasis and drives neurodegeneration. Hsp104 is a hexameric, ring-shaped AAA+ ATPase that dissolves protein aggregates, yet how hexamers translocate and extract polypeptides trapped in mechanically resistant aggregates remains unclear. Using substrates that recapitulate the physical co...
Jia-Bei Lin, Jaskamaljot Kaur Banwait, A. Saurabh et al.
· bioRxiv · 0 citations