Alzheimer's disease (AD) is the most common cause of dementia, with global case numbers projected to reach 153 million in 20501. AD is highly heritable, with twin-based heritability estimates of 60-80%2. Although 1,200 causal loci are predicted to exist for AD3, approximately 80 loci have been associated with AD in two...
E. Uffelmann, D. Wightman, S. Bahrami et al.· Nature· 0 citations
Compared to males, female patients with DLB were less likely to present with Rapid Eye Movement (REM) Sleep Behaviour Disorder, CSF biomarkers showed more Alzheimer’s Disease (AD) co-pathology, potentially contributing to misdiagnosis of DLB.
Heidi Isaksen, K. F. Bru, A. Shadrin et al.· npj Dementia· 0 citations
Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...
J. Thomassen, H. Leonard, Brittany Ulms et al.· Nature Genetics· 0 citations
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