Author

A. Rohou

2 papers indexed here

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Open access Sep 2026

A scalable human neuron model of Alzheimer’s disease relevant tauopathy reveals mechanisms linking Tau fibrillization to synaptic dysfunction

The development of scalable iPSC-neuron models enables tauopathy drug discovery and reconstructs progressive Tau seeding, fibrillization and synaptic dysfunction, and establishes a physiologically relevant, scalable platform for therapeutic screening that connects Tau seed uptake, site-specific phosphorylation, fibril...

J. Lipka, Xiwei Shan, Qiao Zhang et al. · bioRxiv · 0 citations

Open access Sep 2026

Large-scale single-molecule analysis of tau proteoforms

Proteins exist as diverse proteoforms resulting from a combination of genetic variation, alternative splicing and post-translational modifications. Current methods struggle to capture this complexity at the single-molecule level. Here we introduce Iterative Mapping of proteoforms, a method that enables massively parall...

James Joly, V. Budamagunta, Zheng-Jian Zhang et al. · Nature Methods · 1 citation