Author

A. Robaszkiewicz

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Open access Aug 2026

Txn-Txnrd1 system supports redox rewiring during polyaneuploid transition and protects giant cancer cells at new redox homeostasis

Polyaneuploid giant cells (PGCC), which occur more frequently in TP53-mutant tumors, are recognized as a driver of tumor recurrence and therapy resistance, but the mechanisms supporting their survival remain largely unknown. Our results indicate that polyaneuploid transition and subsequent PGCC maturation in drug-resis...

Kinga Kołacz-Milewska, K. Gronkowska, Sylwia Michlewska et al. · bioRxiv · 0 citations

Open access Aug 2026

Lipid anchor engineering controls cell-penetrating arginine-rich peptide presentation for efficient siEGFR liposomal delivery to triple-negative breast cancer cells

The optimized nanocarrier promoted efficient uptake of fluorescent siRNA in MDA-MB-231 cells and achieved functional delivery of anti-EGFR, leading to substantially reduced expression of the target gene at both transcript and protein levels.

P. Białecki, S. Braccia, T. Makowski et al. · bioRxiv · 0 citations