Background Central nervous system (CNS) cancers, including brain cancer, are rare but highly lethal, and risk factors remain poorly understood. Radon, a known lung carcinogen, may affect non-pulmonary sites, including the CNS. Methods We estimated the radon-related hazard of incident malignant CNS cancer in a large Uni...
Carson Mowrer, Eric A. Whitsel, J. Collins et al.· Neuroepidemiology· 0 citations
Most genetic variants associated with complex traits are hypothesized to regulate gene expression. To understand the genetics underlying gene expression variability, we characterized 14,324 RNA-sequencing samples from the Trans-Omics for Precision Medicine program and performed expression and splicing quantitative trai...
Peter Orchard, T. Blackwell, L. Kachuri et al.· Science· 0 citations
This study supports methylation risk scores as novel biomarkers of stress-related CHD and uncovers epigenetic regulation in monocytes as a potential underlying mechanism of stress-related CHD, highlighting biological pathways linking stress and disease and may promote personalized interventions in high-risk populations...
Sofia Benavides, Hazel Milla, Helena Palma-Gudiel et al.· medRxiv· 0 citations
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