Introduction Recovery after traumatic brain injury (TBI) and stroke is heterogeneous, even among patients with similar lesion burden, clinical severity, and rehabilitation exposure. Neuroinflammation is a biologically plausible contributor, but evidence that inflammatory state modifies the effect of a specific rehabili...
R. S. Calabrò, Andrea Calderone, Alessio Ardizzone et al.· Frontiers in Neurology· 0 citations
Freezing of gait (FoG) in Parkinson’s disease is clinically heterogeneous, yet wearable-sensor studies predominantly focus on binary FoG detection. We investigated whether right-ankle inertial signals can characterize clinically meaningful FoG manifestations within a three-stage conditional framework. Accelerometer and...
A. Ielo, L. Bonanno, A. Quartarone et al.· Bioengineering· 0 citations
Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapy for advanced Parkinson's disease (PD), primarily targeting motor complications refractory to pharmacological treatment. However, its long-term impact on functional autonomy and quality of life (QoL) remains debated. Objec...
Laura Culicetto, M. C. De Cola, F. Vitiello et al.· Journal of Parkinson's Disea...· 0 citations
Highlights What are the main findings? Virtual reality (VR) showed the strongest evidence for attention and executive functions. Studies used different levels of immersion, but the available evidence does not permit conclusions regarding their comparative effectiveness. What are the implications of the main findings? V...
Maria Pagano, Irene Cappadona, Anna Anselmo et al.· Healthcare· 0 citations
The findings support the potential role of structural MRI biomarkers combined with interpretable ML approaches for the classification of cognitive impairment and the integration of demographic variables improved model performance, particularly in binary discrimination tasks, whereas multiclass classification remained m...
The severity of depressive symptoms were strongly associated with reduced functional autonomy and the importance of early diagnosis and targeted interventions for depressive symptoms to improve patient management in everyday life is highlighted.
Irene Cappadona, Maria Pagano, Anna Anselmo et al.· Neurodegenerative Disease Ma...· 0 citations
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