Author

A. Puschnik

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Open access Sep 2026

Circulating cholesterol fuels SARS-CoV-2 replication via ORF3a.

High levels of "bad" cholesterol increase the risk of cardiovascular disease and are also linked to more severe COVID-19, though the reason has been unclear. We show that low-density lipoprotein (LDL) directly enhances SARS-CoV-2 RNA replication, especially in the Beta variant. The viral accessory protein ORF3a is both...

J. Hayashi, Taha Y. Taha, Irene P. Chen et al. · EMBO Reports · 0 citations

Open access Jul 2026

Orthogonal CRISPR screens and human liver chimeric mice identify hepatitis B virus host factors

The first pooled, genome-wide CRISPR-Cas9 knockout (KO) screen with authentic HBV infection is performed and these results are integrated with two orthogonal pooled screens to identify host factors to expand the catalog of HBV host factors and provide a scalable framework for host target discovery.

C. A. Freije, Georgios Dangas, Antonis Athanasiadis et al. · bioRxiv · 0 citations