Author

A. Pfenning

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Open access Sep 2026

A molecular and spinal circuit basis for the functional segregation of itch and pain

Summary The dorsal horn is remarkably diverse, yet how this cellular complexity enables discrimination of sensory modalities remains a fundamental question. Neurons expressing gastrin-releasing peptide receptor (Grpr+) have long been considered dedicated to itch, yet broad activation also evokes pain-related behavior....

M. Noh, Kelly A. Corrigan, Sean-Paul G. Williams et al. · Neuron · 0 citations

Open access Aug 2026

Conditional polygenic enrichment distinguishes causal from tagging disease-critical cell populations in single-cell RNA-seq

ScDRS-FM is introduced, a method that disentangles causal from tagging disease associations at single-cell resolution by jointly modeling correlated cell populations to assess conditional polygenic enrichment relative to other cell populations in the dataset; scDRS-FM further leverages single-cell denoising to improve...

A. Turcan, Kangcheng Hou, K. Z. Lin et al. · medRxiv · 0 citations

Open access Aug 2026

An Epigenetic Signature of Vulnerable Neurons is Under Selective Pressure Associated with Longevity Across Placental Mammals

Age is the primary risk factor for neurodegenerative diseases, which are characterized by cell-type-specific vulnerability 1. Yet brain-aging mechanisms remain unclear given the complex, interacting age-associated pathways across diverse neural cell types. Here, we dissect cell type- cell state-specific aging gene regu...

Ghada Abdelhady, Qiao Su, Andrew Z. Wang et al. · bioRxiv · 0 citations