Author

A. Pérez-Martínez

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Review Open access Sep 2026

Naive T cell-depleted hematopoietic stem cell transplantation to minimize immunosuppression after solid organ transplantation: case report

Two solid organ transplant recipients treated with non-myeloablative conditioning followed by naïve T-cell-depleted hematopoietic stem cell transplantation and donor memory T-cell infusions use mixed lymphocyte reactions with TCRβ sequencing to track donor-reactive T-cell clonotypes to support minimization of immunosup...

A. Pérez-Martínez, C. Aguirre-Portolés, C. Mestre-Durán et al. · Communications Medicine · 0 citations

Open access Aug 2026

Tisa-cel and axi-cel CAR structure influences the development of resistance to CD19-CAR-T therapy.

It is shown that CAR structure is a critical determinant of CD19 loss in tumor B cells, and Mathematical modeling indicates that the failure of CD19-4-1BB-based CAR-T cells to eliminate CD19low cells, unlike CD28-based CARs, promotes the expansion of resistant populations.

Marta Krawczyk, K. Fidyt, Narcís Fernandez-Fuentes et al. · Leukemia · 0 citations