Open access
Nov 2025
pH-Sensitive Amino Lipid-Driven Pore Formation Enables Endosomal Escape of Lipid Nanoparticles
Molecular simulations are employed to elucidate how LNPs fuse with the endosomal membrane and release their payloads, and identify multiple fusion pathways, with a dominant stalk-pore mechanism.
A. P. Singh, Kana Shibata, Yusuke Miyazaki et al.
· bioRxiv · 0 citations