A. P. Karlapudi

Structure-based identification of a membrane-retained OmpA candidate against Acinetobacter baumannii by membrane molecular dynamics and phenotypic antibacterial assessment.

Outer membrane protein A (OmpA) contributes to the envelope integrity and virulence of Acinetobacter baumannii and contains a lumenal cavity that may accommodate small molecules. We screened 99,878 ChEMBL-derived compounds against a structural model of the OmpA transmembrane barrel using two rounds of docking followed...

Partial purification and characterisation of an Enterocin P-like bacteriocin from Enterococcus faecium E18

Integrative Single-Cell, Spatial, and Bulk Transcriptomics Characterizes an Outcome-Associated, Spatially Organized Mesenchymal Program in IDH-Mutant Glioma

Simple Summary Gliomas are brain tumors that differ widely in how aggressively they behave and in how long patients survive. We asked whether reproducible patterns of gene activity could point to clinically important features of these tumors. By combining data from individual cells, whole-tumor samples, and intact tiss...