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Open access Aug 2026

Effects of environmentally relevant ibuprofen exposure on ovarian follicular atresia in Wistar rats: A biochemical and immunohistological study

Objective This study aimed to investigate whether chronic exposure to environmentally relevant concentrations of ibuprofen promotes follicular atresia in female rats and to explore potential underlying mechanisms affecting ovarian function. Methods Ten adult female Wistar rats were randomly assigned to two groups (n=5...

Safa Mouaki Benani, S. Benbia, Y. Belkhiri et al. · 0 citations
Open access Aug 2026

Naproxen at environmentally relevant doses modulates ovarian folliculogenesis: Morphometric analysis and Bcl-2 immunohistochemical expression in Wistar rats after chronic exposure.

Objective Naproxen has received considerable attention due to its environmental persistence and incomplete removal during wastewater treatment. This study evaluated the ovarian toxicity of naproxen at an environmentally relevant dose to assess its potential reproductive risks. Methods Female Wistar albino rats were e...

A. Ouadah, S. Benbia, Y. Belkhiri et al. · 0 citations

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