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A. Ostendorf

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Open access Oct 2026

Optical genome mapping identifies clinically relevant somatic structural variation in epilepsy-affected brain tissue.

Somatic variants are a prominent cause of epilepsy-associated cortical malformations, but about half of patients undergoing genetic testing have no finding due partly to limitations in variant detection. Most studies have focused on single-nucleotide variants or small indels that are accessible to short-read sequencing...

Anthony R. Miller, James J. Anderson, Maria E. Hernandez Gonzalez et al. · 0 citations
Review Open access Aug 2026

Effect of time to palliative epilepsy surgery on outcomes.

It is found that the association between early epilepsy surgery and seizure reduction in palliative procedures reflects the heterogeneity of the population, including different types of surgical procedures and lesional and nonlesional epilepsies.

Robert M Crutcher, David E. Horvat, A. Caraway et al. · 0 citations
Open access Oct 2026

Delayed Surgical Evaluation After Drug-Resistant Epilepsy Diagnosis Worsens Outcomes in Children: A Multicenter Study.

Delays from DRE diagnosis were independently associated with reduced seizure freedom, supporting presurgical evaluation within 1 year as an evidence-based quality benchmark, and DRE-to-evaluation interval, not total epilepsy duration, predicted outcomes.

Debopam Samanta, A. Caraway, Andrew T. Knox et al. · 0 citations

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