Changes and clinical impact of HER3 and ERBB3 expression in primary and recurrent ovarian cancer.
OBJECTIVE Human epidermal growth factor receptor (HER) 3, encoded by the ERBB3 gene, transduces signals most effectively when dimerized with HER2. Although HER3 protein expression has been considered a poor prognostic factor in ovarian cancer, limited data exist on changes in HER3 protein expression and ERBB3 messenger...