A. Odugbemi

Exploiting ER proteostasis in malaria: protein disulphide isomerases as selective antimalarial targets.

PfPDI inhibitors are most likely to succeed as components of resistance-robust combination therapies, and progress will depend on structure-guided targeting of divergent non-catalytic surfaces, optimization of intracellular and ER exposure, and rigorous in-parasite target-engagement studies.