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Author

A. Neuhaus

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Aug 2026

Cryo-EM structures of apo human Factor XIa reveal catalytic-domain flexibility and exposure of the Factor IX-binding site

It is demonstrated that FXI activation results in a global reorganization of the homodimer, extending beyond the activation loop to include a significant reorientation of the catalytic domain (CD) relative to the apple-domain (AD) platform.

A. Siutkina, A. Neuhaus, Marvin Taterra et al. · 0 citations

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