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The findings suggest that BBMs, potentially in combination with genetic information, may help identify individuals with a more progressive AD‐related biological profile who may derive greater benefit from multidomain intervention.
A double-cutoff analysis suggest that scans in the 11 to 26 Centiloid range should be interpreted with caution depending on the context of use, and positivity cutoffs converged around 18 Centiloids (data-driven) and 27 Centiloids (visual reads).
The present case demonstrates that RSE with cortical involvement on MRI could be anatomically associated with CLN, which is accompanied by massive infiltration of plasma cells and T lymphocytes, which was seen in the overlying subarachnoid membrane and in the adjacent intact appearing parenchyma.
High-resolution dhPET revealed significantly higher SUVRs in Aβ⁺ compared with Aβ⁻ subjects in supratentorial structures, including cerebral white matter, and in cerebellar gray matter.
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