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A. Mihanfar

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Open access Sep 2026

Diosgenin enhances 5-fluorouracil sensitivity in drug-resistant colorectal cancer cells via inhibition of ATR/Chk1-mediated DNA damage response.

BACKGROUND AND OBJECTIVE Drug resistance to 5-fluorouracil (5-FU) is one of the major challenges in the treatment of colorectal cancer, which is largely associated with the activation of DNA damage response (DDR) pathways, especially the ATR-CHK1 axis, and increased activity of drug efflux pumps. The aim of this study...

Bita Azizzadeh, A. Mihanfar, M. Majidinia · 0 citations

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