Author

A. Mastrangelo

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Open access Oct 2026

Cerebrospinal fluid amyloid and neurodegeneration biomarkers in the diagnosis and prognosis of amyotrophic lateral sclerosis: a multicohort observational study.

BACKGROUND Neurofilament light chain (NfL) is an established biomarker for amyotrophic lateral sclerosis (ALS). However, it remains unclear whether biomarkers reflecting amyloid-β metabolism (Aβ), tau (phosphorylated tau, pTau), and astrogliosis (glial fibrillary acidic protein, GFAP) can complement NfL in clinical app...

Kazuki Obara, S. Janelidze, Daisuke Ito et al. · EBioMedicine · 0 citations

Open access Sep 2026

Changes in five cerebrospinal fluid and three plasma Alzheimer’s disease biomarkers across increasing brain amyloid-beta and tau pathology burden

A sequential model of biomarker changes across the Alzheimer’s disease neuropathological continuum is supported, with CSF Aβ42/Aβ40 best reflects low/intermediate Aβ burden, while CSF p-tau markers are more closely related to high Aβ and intermediate tau load.

A. Mastrangelo, Simone Baiardi, Edoardo Ruggeri et al. · Acta Neuropathologica · 0 citations