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A. Maremmani

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Open access Oct 2026

Stress-Driven Brain Remodeling in Opioid Use Disorder: Toward a Neuroprogressive Model

Background: Opioid use disorder (OUD) is classically understood through reward dysregulation, opponent processes, and allostatic adaptation, but these models only partly account for the persistent cognitive, affective, and stress-regulatory abnormalities observed in some individuals with long-standing OUD. Methods: Thi...

F. Della Rocca, I. Maremmani, M. G. Carbone et al. · 0 citations

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