The relationship between cell cycle length and differentiation competence has been studied in developmental biology, particularly in embryonic stem cells, which show a very short G1 phase required to maintain pluripotency. How and whether this principle operates in cancer— where the cell cycle is deregulated and G1 is...
K. Hayatigolkhatmi, R. Valzelli, E. Ceccacci et al.· bioRxiv· 0 citations
Targeted protein degradation (TPD) has transformed drug discovery by enabling event-driven elimination of pathogenic proteins, but many diseases arise from protein insufficiency and require restoration rather than removal. Deubiquitinase (DUB)-targeting chimeras (DUBTACs) offer a complementary proximity-pharmacology ap...
G. Hailu, Emanuele Fabbrizi, Andrea Mancini et al.· Drug Discovery Today· 0 citations
Advances provide the first chemical foothold for therapeutic modulation of m7G pathways and underscore METTL1 as a promising yet complex target requiring careful biological stratification.
Emanuele Fabbrizi, Gebremedhin S. Hailu, Andrea Mancini et al.· Journal of Medicinal Chemist...· 0 citations
Compound 5, although aqueous solubility issues limited its cellular antiproliferative performance, represents a specific, artifact-free architectural starting point for future selective NOX inhibitor development.
Emanuele Fabbrizi, Andrea Mancini, Chiara Lambona et al.· ACS Medicinal Chemistry Lett...· 0 citations
It is shown that neurogenesis is disrupted at multiple stages of lineage progression in both rodent and human neural stem cell models of Huntington's disease, and a panel of clinically relevant epigenetic compounds hold promise for stage-spanning therapeutic strategies capable of modifying disease trajectory.
Jessica Rosati, A. Casamassa, G. Ruotolo et al.· Cell Death and Differentiati...· 0 citations
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