Brain cells neuroprotection induced by TNF-α and LRP5.
BACKGROUND Acute myocardial infarction (AMI) triggers a systemic inflammatory response that can lead to remote organ damage, including the brain. While the Low-Density Lipoprotein Receptor-Related Protein 5 (LRP5)-mediated canonical WNT pathway is a known regulator of cell survival in peripheral tissues, its role in th...