Abstract Non‐standard amino acids (ncAAs) together with synthetic additions (like caps and linkers) are of wide interest for protein design and pharmaceutical optimization, as they can improve physicochemical properties and possibly reshape protein structure. Their inclusion in experimental structures has not been expl...
Alex Waldherr, Gesa L. Freimann, A. Lupas· Protein Science· 0 citations
Cereblon (CRBN) is widely used in targeted protein degradation, but its ligand space has remained dominated by a narrow set of cyclic imide chemotypes. Here, we show that the accessible CRBN ligand space extends substantially beyond this canonical space. A high-throughput screen of > 40,000 compounds, followed by ortho...
Alexander Herrmann, C. Heim, Samuel A. Maiwald et al.· bioRxiv· 0 citations
Coiled coils are formed by α‐helices winding around each other into superhelical bundles. They are characterized by a specific geometry of interaction, called knobs‐into‐holes, in which residues in the core of the structure mesh regularly along a seam that runs the length of the helices. While these residues are predom...
Marcus D. Hartmann, B. H. Alvarez, Mikel Martinez-Goikoetxea et al.· Protein Science· 0 citations
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