A. Løkkegaard

Striatal Dopaminergic Dysfunction Constrains Motor Invigoration in Parkinson’s Disease

Bradykinesia is a cardinal motor feature of Parkinson’s disease and is characterised by a reduced ability to generate movements with normal speed and force. Although nigrostriatal dopamine loss is regarded as the primary cause, direct human evidence linking dopaminergic degeneration to striatal dysfunction and impaired...