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Review Open access Sep 2026

Rethinking the role of animal models in adaptive deep brain stimulation: From feasibility to mechanistic and disease-modifying insights.

BACKGROUND Adaptive deep brain stimulation (aDBS) has emerged as an advanced neuromodulation approach capable of dynamically adjusting stimulation parameters based on real-time biomarkers, thereby overcoming the limitations of conventional continuous DBS (cDBS). While early animal studies were instrumental in establish...

M. Guidetti, H. Ali, A. Loh et al. · 0 citations
Sep 2026

Optimized Brain Functional MRI for Patients With Deep Brain Stimulation Systems.

BACKGROUND AND OBJECTIVES Deep brain stimulation (DBS) is an established neuromodulation therapy for Parkinson disease and other neurological disorders. Active DBS-functional MRI (fMRI) enables visualization of circuit engagement and may provide objective biomarkers of therapeutic efficacy, yet susceptibility artifacts...

Clement Chow, Sriranga Kashyap, B. Santyr et al. · 0 citations

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