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Author

A. Loffreda

3 papers indexed here

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Open access Sep 2026

Gapmers targeting conserved SARS-CoV-2 single-stranded regions reduce viral load and reshape inflammatory macrophage responses

Summary The COVID-19 crisis is now over, but additional viral strains of SARS-CoV-2 that evade immunity are continuously emerging. We explored the design, evaluation, and optimization of anti-sense oligonucleotides (ASOs) targeting SARS-CoV-2 RNA, with the aim of providing a scalable strategy capable of responding to e...

Greta Gallo, L. Donnici, L. S. Colley et al. · 0 citations
Open access Sep 2026

Inflammatory macrophages promote metastatic potential in Triple-negative Breast Cancer through Integrated Stress Response signaling

The findings establish a macrophage-CXCL10-CXCR3-ISR signaling axis that fuels metastatic behavior in TNBC and identify this pathway as a potential node for therapeutic intervention.

Martina Crippa, Vincenzo Salemme, J. Chauhan et al. · 0 citations
Open access Aug 2026

The dystonia-associated Torsin1A sustains CLCC1 function in membrane fusion of the nuclear envelope for NPC biogenesis.

The conserved membrane protein Chloride Channel CLIC-like protein 1 (CLCC1) is identified as a Torsin1A interaction partner whose absence phenocopies membrane fusion defects caused by Torsin deletion inform a model of nuclear envelope membrane fusion and imply that modulating CLCC1 expression is a promising therapeutic...

D. Maslennikova, Harry J. M. Baird, Xinyue Ding et al. · 3 citations · ⚡1

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