Open access
Sep 2026
Allele-specific expression is associated with lower translational efficiency in mouse embryos and stem cells
An mRNA’s cytoplasmic fate can be shaped by its transcriptional history, its modifications and associated protein complexes. Allele-specific expression (ASE), in which a gene’s two alleles are transcribed unequally, provides a natural experiment given that the alleles can differ in sequence or chromatin state, yet thei...
Dayea Park, A. Liechti, D. Gatfield et al.
· bioRxiv · 0 citations