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Author

A. L. La Spada

2 papers indexed here

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Review Jul 2026

Angiotensin system modulation in focal segmental glomerulosclerosis: pharmacological basis and clinical implications.

INTRODUCTION FSGS is a histological convergence point for biologically distinct conditions: primary immune-mediated, genetic, and secondary adaptive forms, each with its own pharmacological logic. ACE inhibitors and angiotensin receptor blockers have anchored its management for three decades on evidence drawn predomina...

G. Gembillo, Chiara Casuscelli, A. L. La Spada et al. · 0 citations
Open access Aug 2026

Characterization of the frameshift c.515dupC knock-in mouse model of HSPB8-associated myopathy (MFM13) and evaluation of Trehalose as autophagy-modulating therapy

These findings support the value of preclinical models for translational studies, and autophagy enhancement as a potential therapeutic strategy for HSPB8-related myopathy, and evaluated trehalose, a natural disaccharide that induces HSPB8 and enhances autophagy.

Alyaa Shmara, Lan Weiss, A. Gromova et al. · 0 citations

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