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Author

A. Kotschy

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Open access Sep 2026

Photocatalytic Synthesis and Palladium‐Catalyzed Functionalizations of Hydrofluoroolefin (HFO‐1234ze)‐Based Vinyl Iodides

The utilization of low‐impact industrial refrigerants as chemical feedstocks offers a highly sustainable pathway for the synthesis of complex organofluorine compounds. Herein, we report a scalable methodology to access a novel fluoroalkyl iodide building block directly from commercially available HFO‐1234ze gas under g...

B. Varga, Péter Szalai, K. Aradi et al. · 0 citations
#protein folding Open access Aug 2026

Structure‐Guided Optimization of a Molecular Glue Targeting the KBTBD4‐HDAC1/2 Complex

Optimization of UM171, a molecular glue initiating the degradation of neosubstrate HDAC1/2–CoREST–LSD1 through a multiprotein complex formed with KBTBD4, resulted in a 20‐fold improvement in glue activity, demonstrated by the stability of its ternary complex with KBTBD4‐HDAC2.

Timea Baló, Zhuoyao Chen, Laurine Palluaud et al. · 0 citations

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