Open access
Jul 2026
Base editing-derived models of human WDR34 and WDR60 disease alleles replicate retrograde intraflagellar transport (IFT) and hedgehog signaling defects
Base editing derived cell models shed light on the role of ciliary dynein complex components for intraflagellar transport, hedgehog signaling and differential regulation of genes associated with Golgi intracellular transport using human disease alleles.
Dinu Antony, Elif Yilmaz Güleç, A. Klawonn et al.
· Communications Biology · 0 citations