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Open access Sep 2026

Cluster-Based Phenotyping in an HFpEF Population Identifies a Biomarker-High, Atrial-Dysfunction Phenotype with Impaired Quality of Life, Reduced Exercise Capacity and Higher Healthcare Utilization

Background/Objectives: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome. Atrial remodeling represents an important dimension of HFpEF beyond the presence of atrial fibrillation (AF). We aimed to identify clinically meaningful atrial phenotypes using unsupervised clustering. Methods: Ov...

S. Haack, Frank Edelmann, F. Spinka et al. · 0 citations
Open access Sep 2026

Right Ventricular Free Wall Strain Is Associated with Low-Grade Albuminuria in HFpEF: A Cross-Sectional Cohort Study.

Introduction Heart failure with preserved ejection fraction (HFpEF) presents a major health burden worldwide. Up to 40% of HFpEF patients present with elevated urine-albumin-creatinine-ratio levels (UACR). In this subgroup, the risk for adverse cardiovascular (CV) outcomes is increased. Prior studies suggest a correlat...

A. Kind, D. Zurkan, A. M. Chitroceanu et al. · 0 citations

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