Synthesis of β,N-diphosphoryl-substituted α-aminocinnamates via the C,N-diphosphorylation of 2H-azirines.
A method for the synthesis of β,N-diphosphoryl-substituted α-aminocinnamates from 2-bromo-2H-azirine-2-carboxylic esters and trimethyl or triethyl phosphite has been developed. The transformation affords the target phosphoramidates in generally high yields across a broad range of 3-aryl-substituted azirines. A reaction...