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Open access Sep 2026

A Retrospective Analysis of the Association Between Prediabetes and Biomarkers of Intestinal Permeability in Patients with Prediabetes from Durban, South Africa

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insufficient insulin production and diminished insulin receptor sensitivity. Prediabetes, which often precedes T2DM, involves elevated blood glucose levels that do not yet meet T2DM diagnostic criteria. Research has shown that complications linked...

Luyanda Mthethwa, A. Khathi · 0 citations
Open access Sep 2026

Investigating the effect of diet-induced prediabetes on the HPA-axis, sympathetic nervous system and endogenous opioids in male Sprague-Dawley rats

Background Prediabetes is associated with metabolic dysfunction that may disrupt neuroendocrine regulation before the onset of overt type 2 diabetes mellitus. Although previous studies have independently examined alterations in the hypothalamic–pituitary–adrenal (HPA) axis, sympathetic nervous system (SNS), and endogen...

Nompumelelo Anna-Cletta Gumede, Zenele Chonco, A. Khathi · 0 citations

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