Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are unified by pathological α-synuclein (αSyn) aggregation, yet diverge in terms of the cellular distribution of pathology and clinical phenotype. Extracellular vesicles (EVs) have emerged as potential mediators or biomarkers o...
Suman Dutta, Amin Atashgaran, Anis Sahoo et al.· Brain : a journal of neurolo...· 0 citations
Transcription underpins the expression of genetic information and is viewed as a series of independent initiation and termination events. In bacteria, promoters and terminators of transcription are therefore considered distinct regulatory elements. Here, we challenge this view. Genome-scale analyses reveal that promote...
Andrew G. Fletcher, D. Forrest, Charles Cooper et al.· bioRxiv· 0 citations
This work introduces DNA-FLASH (DNA-based FLuorescence Amplification upon Single-target Hybridization), a DNA nanosensor concept for digital biosensing that may support the development of next-generation biosensors capable of addressing pressing global challenges, including rapid disease detection, environmental sustai...
