The inherent instability of mRNA-lipid nanoparticles (LNPs) necessitates ultra-cold storage, creating significant barriers for global distribution and limiting their broader application in advanced delivery systems. Solid-state, water-free formulations offer a promising solution by enhancing thermostability and enablin...
Jin-Bi Tian, Khanh T. M. Tran, Brett H. Pogostin et al.· bioRxiv· 0 citations
The instability of mRNA-lipid nanoparticles (LNPs) necessitates ultra-cold storage, limiting global distribution and their broader application in advanced delivery systems. Solid-state, water-free formulations enhance thermostability and enable integration into emerging delivery modalities such as microneedle patches....
Jin-Bi Tian, Khanh T. M. Tran, Brett H. Pogostin et al.· Nature Biotechnology· 0 citations
Biobanking has played an important role in advancing cell therapy by enabling long-term preservation of cell function, facilitating product transport, and allowing flexibility in infusion scheduling. However, conventional cryopreservation methods rely on high concentrations of dimethyl sulfoxide (DMSO) and serum, which...
Amy H. Lee, Khanh T. M. Tran, Alexander Hostetler et al.· Trends in Biotechnology· 0 citations
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