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Author

A. Inoue

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2 papers indexed here

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Open access Aug 2026

Activation of G12-type G proteins in pancreatic β cells protects against impaired glucose homeostasis

Impaired insulin secretion represents a key feature of type 2 diabetes (T2D), a major global health burden. Insulin release from pancreatic β cells is regulated by G protein–coupled receptors linked to different functional classes of G proteins. The potential metabolic role of β cell G12/13 (G12 hereafter) signaling re...

Srinivas Pittala, Liu Liu, Dhanush Haspula et al. · 0 citations
Open access Sep 2026

Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation

Phospholipase C β (PLCβ) enzymes are activated by heterotrimeric G protein subunits, increasing hydrolysis of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) at the plasma membrane. All four human PLCβ isoforms (PLCβ1–4) are activated by Gαq, whereas PLCβ1–3 are activated to varying extents by Gβγ. The binding sites...

Isaac J. Fisher, Kanishka Senarath, Kennedy Outlaw et al. · 0 citations

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