Author

A. Iavarone

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Open access Sep 2026

Proteogenomic analysis of pediatric and AYA high-grade glioma reveals age-dependent biology, female-male differences, and kinase targets.

High-grade gliomas (HGGs) in children and adolescents and young adults (AYA) exhibit distinct biology across the neurodevelopmental spectrum. To dissect tumor-intrinsic molecular characteristics independent of developmental variation, we perform comprehensive proteogenomic analyses of tumors from 112 HGG patients aged...

N. Tignor, M. Koptyra, Shrabanti Chowdhury et al. · Cell Reports Medicine · 0 citations

Open access Jul 2026

TAZ mediates enhancer reprogramming blocks neuronal differentiation in glioma stem-like cells.

Direct neuronal fate can be achieved by blocking TAZ/HDAC complexes, uncovering a novel mode of cellular differentiation that can be utilized as a non-cytotoxic therapeutic strategy for malignant gliomas.

A. Audia, M. Mattohti, Visweswaran Ravikumar et al. · Scientific Reports · 0 citations

Review Aug 2026

Exploring the landscape of targetable alterations in patients with glioblastoma.

The therapeutic landscape of targeted therapies in glioblastomas is summarized, spanning major target classes including receptor tyrosine kinases, intracellular signalling proteins, cell-cycle dysregulation and synthetic-lethal vulnerabilities and emerging strategies targeting genome integrity and telomeres, epigenetic...

E. Aquilanti, M. Touat, P. French et al. · Nature Reviews Clinical Onco... · 0 citations