The molecular circadian clock optimally coordinates an organism’s physiology with the light/dark cycle. One commonality among circadian molecular clock proteins is that they undergo alternative splicing, yielding multiple proteoforms. The isoform-specific sequences spliced into clock proteins contain intrinsically diso...
Jacqueline F. Pelham, Alex T. Keeley, E. Usher et al.· bioRxiv· 0 citations
This work establishes that multisite phosphorylation of the SPT5 CTR1 domain modulates a heterogeneous interaction landscape shaped by sequence context, and emphasizes the nontrivial difference between serine and threonine phosphorylation as a mechanism to regulate disordered protein structure–function relationships.
Rong Hu, E. Usher, Olivia A Fraser et al.· Journal of Physical Chemistr...· 0 citations
GOOSE is presented, a comprehensive computational framework for the rational design of IDRs that uses rational sequence design as a powerful method for exploring function in IDRs and provides a versatile tool for designing novel, functional disordered proteins.
Kara Hunter, Trevor Brandt, Karina Guadalupe et al.· Nature· 2 citations
It is found that PPTC7 has a moderately ‘weak’ presequence, but this feature is insufficient to promote dual targeting of a generic cargo protein, and sequence-specific features can work combinatorially to impart dual-localization capacity to mitochondrial proteins, enabling functions across cellular compartments.
Youmian Yan, Lianjie Wei, Thomas Schodl et al.· bioRxiv· 0 citations
Biomolecular condensates represent unique microenvironments that organize intracellular biology and promote biochemical reactions. However, the biomolecular interactions driving condensate phase separation are often weak, transient, and heterogeneous. Investigating the structural biology and chemical properties of cond...
Ethan A. Perets, Jacob A. Spies, Justin H. Cheong et al.· Biophysical Journal· 0 citations
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