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Author

A. Henssen

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Open access Sep 2026

MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness

Extrachromosomal DNA (ecDNA) comprises megabase-sized circular DNA elements that frequently carry oncogene amplifications, driving aggressive tumour phenotypes, therapeutic resistance and poor clinical outcomes across many cancers1, 2, 3–4. Although ecDNA is thought to arise from canonical double-strand break repair, t...

David Billing, Monica Selvaraj, M. E. Kelley et al. · 1 citation
Open access Sep 2026

Inverted logic of ecDNA localization converts nuclear periphery into oncogenic transcription hubs in cancer

Extrachromosomal DNA (ecDNA) is a major driver of cancer pathogenesis, however, its spatial organization in the nucleus is not currently understood. Here we show that ecDNAs, in contrast to chromosomal DNA, preferentially localize to the nuclear periphery yet resist peripheral gene silencing. Single-molecule multi-omic...

Yan-Bo Wang, Xiao-Wei Yan, Natasha E. Weiser et al. · 0 citations

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