A. Harduin-lepers

Species-specific disordered regions and temperature dependence of bisecting GlcNAc-synthetic enzyme MGAT3.

MGAT3 (GnT-III) is a glycosyltransferase that catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the central β-mannose in N-glycans, generating bisecting GlcNAc. These bisecting GlcNAc-bearing N-glycans are implicated in cancer and Alzheimer's disease and negatively regulate N-glycan maturation. Although the bio...