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Open access Sep 2026

Population-Scale Precision Safety in Oncology Reveals Clinical and Genetic Determinants of Systemic Therapy Toxicity

MSK-Tox provides an empirical basis for a new precision safety paradigm for predicting who will be harmed by a therapy on the same principles that guide prediction of therapeutic benefit, and identifies two modes of germline susceptibility to treatment toxicity.

Z. Bakouny, X. Guo, F. Huang et al. · 0 citations
Open access Aug 2026

Developmental reversion underlies resistance to immune checkpoint blockade in kidney cancer

An atlas of ccRCC tumors is assembled combining single-cell RNA sequencing and imaging-based spatial transcriptomics to suggest reversion to embryonic nephrogenesis as a defining feature of persister cells in ccRCC, nominating the nephrogenic developmental program and its associated inhibitory checkpoint repertoire as...

Dig V.K. Yarlagadda, Zhenghan Wang, Hui Jiang et al. · 0 citations

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