Jul 2026
SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry
It is shown that DNMT1 is enriched at unmethylated CpG islands of actively transcribed genes largely by its CXXC domain, and RFN4-mediated SUMOylation enhances DNMT1 mobility and DNA methylation, thereby promoting the suppression of endogenous retroviral element-dependent viral mimicry.
Brian J. Liddicoat, Jesse J. Balic, W. Jia et al.
· Nature Genetics · 1 citation