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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

A. Gronenborn

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Sep 2026

Simultaneous Site- and Residue-Specific Incorporation of Fluorinated Amino Acids for In-Cell Structural Biology by 19F Magic Angle Spinning NMR Spectroscopy

A 19F-labeling strategy is reported that combines site-specific incorporation of 4-(trifluoromethyl)-l-phenylalanine (tfmF) via genetic code expansion with fluorination of all tryptophan residues at the 7 position of the indole ring to expand the toolbox of 19F MAS NMR for cellular structural biology.

Kumar Tekwani Movellan, A. Gronenborn, Tatyana Polenova · 0 citations

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