Open access
Jul 2026
Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.
To define mutation-specific lineage reversion and tumor initiation, Ptf1a-tdTomato mice and multiple KRAS mutants are implemented across several genetic, pharmacologic, and inflammatory perturbations in vivo to deciphering mutation-specific oncogenic trajectories and directing the implementation of KRAS-directed therapeutics.
A. Grimont, David Falvo, W. Sisso et al.
· Developmental Cell · 1 citation