BACKGROUND
GEO-CM04S1 is a synthetic modified vaccinia Ankara (sMVA)-based SARS-CoV-2 vaccine expressing Spike (S) and Nucleocapsid (N) antigens derived from the ancestral Wuhan-Hu-1 reference strain. This phase 2 study evaluated the safety and immunogenicity of two GEO-CM04S1 dose levels administered as a single boost...
Sandra Ortega-Francisco, Maria Teresa Prudente de Aquino, F. Chiuppesi et al.· Journal of Infection· 0 citations
Tissue-resident immunity constitutes a first line of defence against pathogens and enables rapid innate and adaptive memory responses1-3. However, experimental studies have been hindered by a lack of holistic human in vitro models that enable epithelial infection in the context of tissue-resident immune subsets. In lun...
J. Rathkey, Shannon S. Choi, V. van Unen et al.· Nature· 0 citations
This work identified Conserved T cell Epitope Regions (CTERs) derived from conserved sequences within OWA and NWA, using LASV and JUNV as respective prototypes and represents an initial step toward the development of a pan-arenavirus T-cell vaccine.
Ziyin Wang, Margret Kim, A. Zúñiga et al.· Journal of Immunology· 0 citations
The results emphasize the importance of conserved and cross-reactive responses in vaccine immunogenicity, providing a mechanism through which repeated boosting enhances vaccine immunogenicity in SOTRs and other immunocompromised populations.
Georgia Stavrakis, Katerina Roznik, Laila Stoddart et al.· Frontiers in Immunology· 0 citations
It is suggested that spike-based bivalent vaccination alone cannot direct a T-cell focused response to achieve broad immunity across the BetaCoronavirus family, and incorporation of additional protein sequences will likely be required to shift response toward the CTER approach.
Ziyin Wang, Nematullah Waseem, Naomi Peisajovich et al.· Journal of Immunology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
